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Merck

SIRNA

MISSION® siRNA Product Offerings

Custom and Predesigned siRNA

Synonym(s):

Custom siRNA, High-throughput siRNA, Predesigned siRNA, siRNA, siRNA pools

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UNSPSC Code:
12352208

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Fuhui Xu et al.
PloS one, 9(9), e106509-e106509 (2014-09-04)
Improved drought tolerance is always a highly desired trait for agricultural plants. Significantly increased drought tolerance in Arabidopsis thaliana (Columbia-0) has been achieved in our work through the suppression of ESKMO1 (ESK1) gene expression with small-interfering RNA (siRNA) and overexpression
Antonis C Antoniou et al.
The New England journal of medicine, 371(6), 497-506 (2014-08-08)
Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. We analyzed the risk of breast cancer among 362 members of
Chong He et al.
PLoS genetics, 10(12), e1004860-e1004860 (2014-12-19)
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces
Maria Dermit et al.
Developmental cell, 55(3), 298-313 (2020-11-11)
Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a
Yanli Ma et al.
PloS one, 7(10), e47961-e47961 (2012-11-01)
Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF
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Articles

预设计siRNA

Rosetta siRNA设计算法通过优化siRNA序列来降低脱靶效应并提高RNAi的性能。

定制新一代测序寡核苷酸

无论新一代测序 (NGS) 平台如何变化，都需要通用和索引接头序列来正确组装样品片段。

定制 cGMP 寡核苷酸

如果您计划进行分子诊断(MDx)商业化，开发实验室开发试验(LDT)，或进行治疗学临床前研究，最终的成品试剂盒、检测试剂或药品必须具有非凡的质量水平，符合严苛的监管或研究标准。

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定制 cGMP 寡核苷酸

如果您计划进行分子诊断(MDx)商业化，开发实验室开发试验(LDT)，或进行治疗学临床前研究，最终的成品试剂盒、检测试剂或药品必须具有非凡的质量水平，符合严苛的监管或研究标准。

定制cGMP寡核苷酸将于2023年上市

如果您计划进行分子诊断(MDx)商业化，开发实验室开发试验(LDT)，或进行治疗学临床前研究，最终的成品试剂盒、检测试剂或药品必须具有非凡的质量水平，符合严苛的监管或研究标准。

定制siRNA

通过强大的 RNA 干扰科技，可使用合成的小干扰 RNA (siRNA) 实现成功的基因沉默。研究人员正通过让这些长度通常为 19-23 个碱基的小型合成寡核苷酸靶向特定的目标基因，发现基因功能、阐明通路并筛选潜在的新药靶点。

阳性对照siRNA

MISSION阳性对照siRNA采用Rosetta siRNA设计算法，可作为所有siRNA沉默实验的理想互补选择。所有MISSION阳性对照siRNA均已通过性能验证，让您可腾出更多时间沉默自己的目标基因，无需为优化内参花费太多时间。

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Global Trade Item Number

SKUGTIN
71115-3CN07790788053055
71115-4CN07790788053062

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