SML1538
NMDI14
≥97% (HPLC), nonsense-mediated RNA decay inhibitor, powder
Synonym(s):
4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
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About This Item
Empirical Formula (Hill Notation):
C21H25N3O4S
CAS Number:
Molecular Weight:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
NMDI14, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 0.2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O
InChI key
QRLPSNLBUMVXBL-UHFFFAOYSA-N
Application
NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
- to study its effects on differentiating cardiomyocytes
- to study its effects on zebrafish pdzk1 gene-knockout embryos
- to analyze its effects on the apoptosis of colorectal cancer cells
Biochem/physiol Actions
NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Potent nonsense-mediated RNA decay (NMD) inhibitor
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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