139181
Bromodichloromethane
≥97%
Synonym(s):
Dichlorobromomethane
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About This Item
Linear Formula:
BrCHCl2
CAS Number:
Molecular Weight:
163.83
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-856-7
Beilstein/REAXYS Number:
1697005
MDL number:
Assay:
≥97%
Form:
liquid
Quality Level
assay
≥97%
form
liquid
contains
potassium carbonate as stabilizer
refractive index
n20/D 1.497 (lit.)
bp
87 °C (lit.)
mp
−55 °C (lit.)
solubility
water: insoluble
density
1.98 g/mL at 25 °C (lit.)
functional group
bromo, chloro
SMILES string
ClC(Cl)Br
InChI
1S/CHBrCl2/c2-1(3)4/h1H
InChI key
FMWLUWPQPKEARP-UHFFFAOYSA-N
Application
Bromodichloromethane was used to investigate the in vivo genotoxicity of chlorodibromomethane, bromodichloromethane and bromoform in mice.
Biochem/physiol Actions
Bromodichloromethane (BDCM) induces steatohepatitic injury in human liver. BDCM induces the cell proliferation in different tissues and kidney damage by renal tuble cell proliferation in male F344 rats.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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K J Stocker et al.
Mutagenesis, 12(3), 169-173 (1997-05-01)
Chlorination of drinking water results in the formation of chlorodibromomethane, bromodichloromethane and bromoform. These trihalomethanes have all shown evidence of genotoxicity in bacterial and mammalian cell systems in vitro and some evidence of carcinogenicity in rodents. Chlorodibromomethane and bromodichloromethane have
Suvarthi Das et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(12), G950-G963 (2013-10-26)
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanisms that link these important events in NASH remain unclear. In this study, we investigated the mechanistic role of purinergic
Ted Lock et al.
Archives of toxicology, 78(7), 410-417 (2004-05-14)
Male F344 rats exposed to bromodichloromethane (BDCM) by gavage at 50 or 100 mg/kg/day for 5 days a week for 28 days excreted large amounts of formic acid in their urine, which was accompanied by a change in urinary pH.