Skip to Content
Merck

Key Documents

View All Documentation

1.00563

ortho-Phosphoric acid

85%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPE, NF

Synonym(s):

Phosphoric acid, o-Phosphoric acid, Orthophosphoric acid, Orthophosphoric acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
H3PO4
CAS Number:
7664-38-2
Molecular Weight:
98.00
E Number:
E338
UNSPSC Code:
12352301
Beilstein/REAXYS Number:
1921286
MDL number:
MFCD00011340
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

500

agency

BP, ChP, JPE, NF, Ph. Eur.

vapor density

3.4 (vs air)

vapor pressure

2.2 mmHg ( 20 °C), 5 mmHg ( 25 °C)

product line

EMPROVE® EXPERT

form

liquid

concentration

85%

technique(s)

API processing | salt formation: suitable

pH

<0.5 (20 °C, 100 g/L in H2O)

kinematic viscosity

30.5 cSt(20 °C)

bp

158 °C (lit.)

mp

~40 °C (lit.)

density

1.685 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OP(O)(O)=O

InChI

1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

InChI key

NBIIXXVUZAFLBC-UHFFFAOYSA-N

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Phosphoric acid can be used as acidifying agent in a variety of pharmaceutical formulations and processes.

Analysis Note

The following cations are harmonized with the ICH Q3D limits:
  • Cadmium (Cd): from <= 0.0001% to <= 0.000020%
  • Mercury (Hg): from <= 0.0001% to <= 0.000030%
  • Lead (Pb): from <= 0.0001% to <= 0.000050%
  • Copper (Cu) gets 1 NKS more: from <= 0.002% to <= 0.0020%
The batch values are set to 30% of the Option 1 limit in each case. The MiBio parameters TAMC and TYMC are set to statistical testing and analyzed only once a year (periodic testing).

Other Notes

Concentrated phosphoric acid is approx. 85% H3PO4 (aqueous).

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Still not finding the right product?

Explore all of our products under ortho-Phosphoric acid

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

8B - Non-combustible corrosive hazardous materials

flash_point_f

does not flash

flash_point_c

does not flash

Stay compliant with GMP using the Emprove® Program

Accelerate qualification, maintain compliance, and save time with Emprove® Dossiers.

Download Dossiers

Note: you will be brought to EmproveSuite.com. Your username and password are separate from SigmaAldrich.com and may differ.

Register for free and access Emprove® Dossiers within minutes. Upgrade your subscription plan to unlock advanced and customized content in the Emprove® Suite

Not finding what you are looking for? Visit the Emprove® Program Help page.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library