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About This Item
Empirical Formula (Hill Notation):
C24H39N5O5
CAS Number:
Molecular Weight:
477.60
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
NBD Sphingosine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810205P-250ug), pkg of 1 × 50 μg (810205P-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810205P
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C21
InChI key
MNFOPKRTMFDMJV-HCEDEFRUSA-N
General description
Sphingosine is the most bioactive sphingoid and a constituent of cell membrane. NBD sphingosine is a derivative of sphingosine tagged with the fluorophore, 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) group.
Application
NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol has been used to measure sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPK2) activity. NBD Sphingosine may be used as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine(PE)-containing liposomes and to label sphingosine kinase 1 (SphK1) to determine its role in endocytic membrane trafficking.
Biochem/physiol Actions
Sphingosine is the precursor of ceramide. It plays a major role as a selective inhibitor of protein kinase C.
Packaging
5 mL Amber Glass Screw Cap Vial (810205P-250UG)
5ML Amber Glass Screw Cap Vial (810205P-50UG)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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