218705
Casein Kinase I Inhibitor, D4476
InSolution, ≥95%
Synonym(s):
InSolution Casein Kinase I Inhibitor, D4476
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About This Item
Empirical Formula (Hill Notation):
C23H18N4O3
Molecular Weight:
398.41
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CK1, CK1d
CK1, CK1d
Product competes with ATP.
Reversible: no
Target IC50: 0.2 µM, 0.3 µM against CK1, CK1d, respectively
Packaging
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
Physical form
A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Preparation Note
Following initial use, aliquot and refrigerate (4°C).
Other Notes
Rena, G., et al. 2004. EMBO Reports5, 60.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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