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Merck

219427

Cathepsin L Inhibitor III

The Cathepsin L Inhibitor III controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin L Inhibitor III, Z-FY( t-Bu)-DMK, Z-FY(t-Bu)-DMK

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About This Item

Empirical Formula (Hill Notation):
C31H34N4O5
Molecular Weight:
542.63
NACRES:
NA.77
UNSPSC Code:
12352200
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Product Name

Cathepsin L Inhibitor III, The Cathepsin L Inhibitor III controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to light yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cathepsin L
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

Other Notes

Z-Phe-Tyr(t-Bu)-diazomethylketone
Shaw, E., et al. 1993. FEBS Lett. 334, 340.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

General description

An irreversible inhibitor of Cathepsin L (Cat. No. 219402 ). About 10,000-fold more effective against cathepsin L than cathepsin S.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cong Zeng et al.
bioRxiv : the preprint server for biology (2021-06-09)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the global COVID-19 pandemic. Herein we provide evidence that SARS-CoV-2 spreads through cell-cell contact in cultures, mediated by the spike glycoprotein. SARS-CoV-2 spike is more efficient

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