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Merck

238811

Cdk9 Inhibitor II

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Cdk9 Inhibitor II, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol

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About This Item

Empirical Formula (Hill Notation):
C9H10N6O
CAS Number:
140651-18-9
Molecular Weight:
218.22
MDL number:
MFCD09262258
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

[nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N

InChI

1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)

InChI key

AYZRKFOEZQBUEA-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cdk9
Product competes with ATP.
Reversible: no
Target IC50: 350 nM, using Cdk9/T1

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.

Other Notes

Krystof, V., et al. 2006. J. Med. Chem.49, 6500.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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