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Merck

P4722

Pyridoxine hydrochloride

meets USP testing specifications

Synonym(s):

Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
58-56-0
Molecular Weight:
205.64
NACRES:
NA.21
PubChem Substance ID:
24898493
eCl@ss:
34058008
UNSPSC Code:
12352205
EC Number:
200-386-2
MDL number:
MFCD00012807
Beilstein/REAXYS Number:
3632435

Key Documents

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InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

biological source

synthetic (organic)

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

Quality Level

200

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General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B6 include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B6 in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBS8300
SLBQ6120V
SLBQ6112V
SLBL8140V
090M1621V

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Nutritional neuropathies
Hammond N, et al.
Neurologic Clinics, 31(2), 477-477 (2013)
B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin
Calderon-Ospina CA, et al.
CNS Neuroscience & Therapeutics (2019)
Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat
Kuypers NJ and Hoane MR
Journal of Neurotrauma, 27(7), 1275-1282 (2010)
Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows
Castagnino DS, et al.
Journal of Dairy Science, 99(3), 1884-1894 (2016)
Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper (II) hexacyanoferrate (III) modified carbon paste electrode
Teixeira MFS, et al.
Journal of the Brazilian Chemical Society, 14(2), 316-321 (2003)
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