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B1427

H-89 dihydrochloride hydrate

Name: H-89 dihydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder, PKA inhibitor

Synonym(s):

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₀BrN₃O₂S · 2HCl · xH₂O

CAS Number:

130964-39-5

Molecular Weight:

519.28 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24278256

NACRES:

NA.77

MDL number:

MFCD11045926

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

H-89 dihydrochloride hydrate, ≥98% (HPLC), powder

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1

InChI

1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;

InChI key

GKFFJFGBWAGAFD-HZBIHQSRSA-N

Gene Information

human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

Description

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

Selective, potent inhibitor of cAMP-dependent protein kinase.

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K⁺) current in rat myocytes. It mediates Na⁺ transport by interacting with α subunits of epithelial Na⁺ channel (ENaC).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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