C1335
S-(−)-Carbidopa
≥98% (TLC), powder
Synonym(s):
(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
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About This Item
Empirical Formula (Hill Notation):
C10H14N2O4
CAS Number:
Molecular Weight:
226.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
249-271-9
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Quality Segment
assay
≥98% (TLC)
form
powder
solubility
methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
InChI
1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
InChI key
TZFNLOMSOLWIDK-JTQLQIEISA-N
Gene Information
human ... DDC(1644)
General description
Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.
Biochem/physiol Actions
Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H2O2 in these cell lines, which are sensitive to reactive oxygen species.
Peripheral inhibitor of L-aromatic amino acid decarboxylase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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