H9268
Hexadimethrine bromide
≥94% (titration)
Synonym(s):
1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, Polybrene
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About This Item
assay
≥94% (titration)
storage temp.
2-8°C
SMILES string
BrCCCBr.N(CCCCCCN(C)C)(C)C
InChI
1S/C10H24N2.C3H6Br2/c1-11(2)9-7-5-6-8-10-12(3)4;4-2-1-3-5/h5-10H2,1-4H3;1-3H2
InChI key
KZKAYEGOIJEWQB-UHFFFAOYSA-N
General description
Hexadimethrine bromide is a quaternary ammonium compound which works as a heparin antagonist. It is also involved in the transformation of low molecular weight DNA.
Application
Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.
Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant.
Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Redei GP
Encyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)
S Kawai et al.
Molecular and cellular biology, 4(6), 1172-1174 (1984-06-01)
A new procedure for DNA transfection has been developed in a system of chicken embryo fibroblast cells and cloned Rous sarcoma virus DNA by using a polycation reagent as a mediator to adsorb DNA to the cell surface and dimethyl
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.
Hershko T
The Journal of Biological Chemistry, 281, 31309-31309 (2006)