M6518
Macrophage Colony-Stimulating Factor human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
MCSF
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About This Item
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
dimer 37 kDa
Impurities:
≤1.000 EU/μg
Product Name
Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
0.500-5.000 ng/mL ED50
quality
endotoxin tested
mol wt
dimer 37 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
General description
Macrophage Colony-Stimulating Factor (M-CSF) is a hematopoietic growth factor, which modulates the proliferation, differentiation and functional activation of monocytes. It is produced by fibroblasts, endothelial cells and bone marrow stromal cells. MCSF stimulates the functions of mature monocytes and macrophages.
Application
Macrophage Colony-Stimulating Factor human has been used for the differentiation of bone marrow-derived macrophages (BMDMs) and human monocyte-derived macrophages (MDMs). It has also been used for cell culture.
Biochem/physiol Actions
Macrophage colony-stimulating factor (M-CSF) augments many of the physiological functions of macrophages, and support osteoclast differentiation.
Physical form
Lyophilized from a sterile filtered buffered solution.
Analysis Note
The proliferative activity is tested in culture using the cytokine-dependent murine monocytic cell line M-NFS-60 cells.
Other Notes
159 amino acids including N-terminal methionine (each monomer).
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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