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Merck

P9767

Sodium palmitate

≥98.5%

Synonym(s):

Hexadecanoic acid sodium salt, Palmitic acid sodium salt

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About This Item

Linear Formula:
CH3(CH2)14COONa
CAS Number:
408-35-5
Molecular Weight:
278.41
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
24899061
EC Number:
206-988-1
Beilstein/REAXYS Number:
3575882
MDL number:
MFCD00002749

Key Documents

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InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

biological source

plant (palm)

assay

≥98.5%

form

powder

mp

283-290 °C (lit.)

functional group

ester

lipid type

saturated FAs

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

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Application

Sodium palmitate (PA) has been used:
  • to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
  • to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
  • as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG3426
SLCG7895
SLCC8775
SLBW9894
SLBV2022

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Chemical composition of everyday products (2005)
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
Nicolas J Pillon et al.
Cell communication and signaling : CCS, 10(1), 30-30 (2012-10-20)
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of cytokines which in turn impact on the surrounding tissue. However
Hepatitis B virus X protein induces hepatic steatosis by enhancing the expression of liver fatty acid binding protein
Wu Y, et al.
Journal of Virology, 90(4), 1729-1740 (2016)
Linnéa Eriksson et al.
Cardiovascular diabetology, 11, 27-27 (2012-03-23)
The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early event in the pathogenesis of atherogenesis and cardiovascular
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