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T2501

L-Thyroxine sodium salt pentahydrate

Name: <SC>L</SC>-Thyroxine sodium salt pentahydrate
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), Thyroid hormone, powder

Synonym(s):

3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄

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About This Item

Linear Formula:

HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O

CAS Number:

6106-07-6

Molecular Weight:

888.93

NACRES:

NA.32

PubChem Substance ID:

24900041

UNSPSC Code:

51111800

EC Number:

200-221-4

MDL number:

MFCD00149110

Beilstein/REAXYS Number:

5721845

Biological source:

synthetic (organic)

Form:

powder

Assay:

≥98% (HPLC)

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Properties

Product Name

L-Thyroxine sodium salt pentahydrate, ≥98% (HPLC), powder

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

mp

207-210 (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1

InChI key

JMHCCAYJTTWMCX-QWPJCUCISA-M

Gene Information

mouse ... Cnr2(12802)
rat ... Cnr1(25248)

Description

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Preparation Note

L-Thyroxine sodium salt pentahydrate dissolves in 4 N NH4OH in methanol at 50 mg/ml to yield a clear to hazy, colorless to yellow solution.

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pictograms

GHS08

signalword

Danger

hcodes

H372

pcodes

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c