56485
N-Hydroxysulfosuccinimide sodium salt
≥98% (HPLC), for peptide synthesis
Synonym(s):
Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt, Sulfo-NHS
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About This Item
Empirical Formula (Hill Notation):
C4H4NNaO6S
CAS Number:
Molecular Weight:
217.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Beilstein/REAXYS Number:
6359129
Product Name
N-Hydroxysulfosuccinimide sodium salt, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
composition
carbon, 20.90-22.68 (anhydrous), nitrogen, 6.10-6.61 (anhydrous)
reaction suitability
reaction type: Addition Reactions
impurities
≤4% water
application(s)
peptide synthesis
functional group
imide, sulfonic acid
SMILES string
[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O
InChI
1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1
InChI key
RPENMORRBUTCPR-UHFFFAOYSA-M
Application
N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Sulfo-NHS is used for preparing hydrophilic active esters, e.g. for crosslinking agents
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Xiao-Yan Xu et al.
Journal of materials chemistry. B, 7(32), 4963-4972 (2019-08-15)
The construction of antibacterial and antitumor coatings could offer effective routes to improve the therapeutic effects of non-vascular stents for unresectable obstructions caused by malignant tumours. Herein, polyelectrolyte multilayers have been explored as bactericidal coatings with controlled antitumor drug release.
N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
Ning Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14633-14638 (2016-12-09)
Nanomaterial-based field-effect transistor (FET) sensors are capable of label-free real-time chemical and biological detection with high sensitivity and spatial resolution, although direct measurements in high-ionic-strength physiological solutions remain challenging due to the Debye screening effect. Recently, we demonstrated a general