901494
N-Methylated pomalidomide
≥98%
Synonym(s):
4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, E3 Ligase ligand methylated negative control, Ligand for PROTAC® research
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About This Item
Empirical Formula (Hill Notation):
C14H13N3O4
CAS Number:
Molecular Weight:
287.27
MDL number:
UNSPSC Code:
12352101
NACRES:
NA.22
Assay:
≥98%
Form:
powder or crystals
ligand
N-Methylated Pomalidomide
Quality Segment
assay
≥98%
form
powder or crystals
reaction suitability
reagent type: ligand
shipped in
wet ice
storage temp.
2-8°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
InChI
1S/C14H13N3O4/c1-16-10(18)6-5-9(13(16)20)17-12(19)7-3-2-4-8(15)11(7)14(17)21/h2-4,9H,5-6,15H2,1H3
InChI key
YSWQOCGODHPKED-UHFFFAOYSA-N
Application
N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
Other Notes
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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