902543
Propargyl-PEG4-acid
Synonym(s):
4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH2CO2H
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About This Item
Empirical Formula (Hill Notation):
C12H20O6
CAS Number:
Molecular Weight:
260.28
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
form
liquid
reaction suitability
reagent type: linker
availability
available only in USA
refractive index
n
density
1.164 g/mL
functional group
alkyne, carboxylic acid
storage temp.
−20°C
SMILES string
OC(CCOCCOCCOCCOCC#C)=O
InChI key
WMBXAUWIPBFEOK-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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