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902675

BocNH-PEG₆-acid

Name: BocNH-PEG<SUB>6</SUB>-acid
Brand: ALDRICH

Synonym(s):

2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₇NO₁₀

CAS Number:

391684-36-9

Molecular Weight:

439.50

UNSPSC Code:

12352106

NACRES:

NA.22

MDL number:

MFCD30489670

Form:

liquid

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Properties

form

liquid

reaction suitability

reagent type: linker

refractive index

n/D 1.4657

functional group

Boc, amine, carboxylic acid

storage temp.

−20°C

SMILES string

OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

InChI

1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)

InChI key

ZKCDWMFMVAYYED-UHFFFAOYSA-N

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Other Notes

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol

Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterization

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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