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1.04220

Guanidinium chloride

LAB

Synonym(s):

Guanidine hydrochloride, Guanidinum hydrochloride, Carbamimidoylazanium chloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
50-01-1
Molecular Weight:
95.53
UNSPSC Code:
12352107
NACRES:
NA.21
EC Index Number:
200-002-3
MDL number:
MFCD00013026
Beilstein/REAXYS Number:
3591990
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Quality Segment

100

potency

655.3-907.1 mg/kg LD50, oral (Rat), >2000 mg/kg LD50, skin (Rabbit)

pH

4.5-5.5 (20 °C, 100 g/L in H2O)

mp

180-185 °C (lit.), 188 °C

solubility

2150 g/L

density

1.3 g/cm3 (lit.)

bulk density

550‑620 kg/m3

storage temp.

2-30°C

SMILES string

Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Analysis Note

Assay (perchloric acid titration): ≥ 99.0 %
Identity (IR-spectrum): passes test
pH-value (10 %; water): 4.5 - 5.5
Melting range: 182 - 186
Chloride (calc. on anhydrous substance): 36.1 - 37.1 %

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pictograms

Exclamation mark
GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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