E9145
Estrone 3-sulfate potassium salt
≥98%
Synonym(s):
1,3,5(10)-Estratrien-17-one 3-sulfate
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About This Item
Linear Formula:
C18H21O5SK
CAS Number:
Molecular Weight:
388.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
214-985-1
MDL number:
Form:
powder
Assay:
≥98%
Quality Level
assay
≥98%
form
powder
contains
~35% Tris as stabilizer
color
off-white to light tan
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
−20°C
SMILES string
[K].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
InChI
1S/C18H22O5S.K.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1
InChI key
XFQXTMKDDYWSBS-DLEHHZMWSA-N
Biochem/physiol Actions
The most abundant estrogen in adult human circulation. Conversion to estradiol requires steroid sulfatase activity. This activity was used to evaluate freshly resected bone fragments against cultured osteoblasts and osteosearcoma cells as models for studying human bone metabolism.
Packaging
Package size based on steroid content
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
L M M C Sousa et al.
Placenta, 33(10), 788-794 (2012-07-31)
Our objectives were to investigate the possible role of VEGFA in bovine placenta steroid synthesis and to determine whether cloned derived placental cells present similar responses as non-cloned ones. Placental cells from cloned (term) and non-cloned (days 90, 150, 210