P9767
Sodium palmitate
≥98.5%
Synonym(s):
Hexadecanoic acid sodium salt, Palmitic acid sodium salt
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About This Item
Linear Formula:
CH3(CH2)14COONa
CAS Number:
Molecular Weight:
278.41
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-988-1
Beilstein/REAXYS Number:
3575882
MDL number:
biological source
plant (palm)
Quality Level
assay
≥98.5%
form
powder
mp
283-290 °C (lit.)
functional group
ester
lipid type
saturated FAs
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].CCCCCCCCCCCCCCCC([O-])=O
InChI
1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
InChI key
GGXKEBACDBNFAF-UHFFFAOYSA-M
Application
Sodium palmitate (PA) has been used:
- to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
- to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
- as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining
Biochem/physiol Actions
Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Chemical composition of everyday products (2005)
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
Nicolas J Pillon et al.
Cell communication and signaling : CCS, 10(1), 30-30 (2012-10-20)
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of cytokines which in turn impact on the surrounding tissue. However