Key Documents

View All Documentation

44583

Doxorubicin hydrochloride

Name: Doxorubicin hydrochloride
Brand: SIGMA

suitable for fluorescence, 98.0-102.0% (HPLC)

Synonym(s):

DOX, Hydroxydaunorubicin hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₉NO₁₁ · HCl

CAS Number:

25316-40-9

Molecular Weight:

579.98

UNSPSC Code:

51281818

NACRES:

NA.76

PubChem Substance ID:

57650234

EC Number:

246-818-3

Beilstein/REAXYS Number:

4229251

MDL number:

MFCD00077757

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

synthetic

Quality Level

200

assay

98.0-102.0% (HPLC)

form

solid

color

orange to dark red

mp

216 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL, clear, orange to red, DMSO: soluble, THF: soluble, ethanol: soluble, methanol: soluble

fluorescence

λ_em 580-590 nm

suitability

suitable for fluorescence

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

Gene Information

human ... TOP2A(7153)

Description

General description

Chemical structure: tetracycline

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Still not finding the right product?

Explore all of our products under Doxorubicin hydrochloride

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H340,H350,H360FD

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c