B4261
Biocytin
≥98% (TLC), suitable for drug transporter assays
Synonym(s):
Bct, Nε-(+)-Biotinyl-L-lysine
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About This Item
Empirical Formula (Hill Notation):
C16H28N4O4S
CAS Number:
Molecular Weight:
372.48
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
97197
Product Name
Biocytin, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
optical activity
[α]20/D +53°, c = 1.05% in 0.1 M NaOH(lit.)
technique(s)
drug transporter assay: suitable
color
white to off-white
mp
~245 °C (dec.) (lit.)
storage temp.
−20°C
SMILES string
[H][C@]12CS[C@@H](CCCCC(=O)NCCCC[C@H](N)C(O)=O)[C@@]1([H])NC(=O)N2
InChI
1S/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1
InChI key
BAQMYDQNMFBZNA-MNXVOIDGSA-N
Application
Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues. Biocytin has been used to label neurons, medium spiny neurons and optic nerves.
Biochem/physiol Actions
Biocytin is an adduct of lysine and biotin. It is hydrolyzed by biotinidase, which acts on peptide-incorporated biotin or free biotin. Biocytin acts as a coenzyme.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Cytometry (2000)
Dbx1 precursor cells are a source of inspiratory XII premotoneurons
Ann L Revill
eLife, 4, e12301-e12301 (2015)
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson?s disease
William A
Neurobiology of Disease (2014)