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C8138

Chlorpromazine hydrochloride

Name: Chlorpromazine hydrochloride
Brand: SIGMA

≥98% (TLC), powder, D2 dopamine receptor antagonist

Synonym(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉ClN₂S · HCl

CAS Number:

69-09-0

Molecular Weight:

355.33

NACRES:

NA.77

PubChem Substance ID:

57654045

UNSPSC Code:

12352200

EC Number:

200-701-3

MDL number:

MFCD00012654

Beilstein/REAXYS Number:

3779989

Assay:

≥98% (TLC)

Form:

powder

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Properties

Product Name

Chlorpromazine hydrochloride, ≥98% (TLC)

Quality Segment

200

assay

≥98% (TLC)

form

powder

mp

194-196 °C

solubility

water: 50 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR2A(3356)

Description

Application

Chlorpromazine hydrochloride has been used:

as an antagonists for calmodulin kinase
as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301,H330

pcodes

P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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