I5659
Idebenone
≥98% (HPLC), powder
Synonym(s):
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
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About This Item
Empirical Formula (Hill Notation):
C19H30O5
CAS Number:
Molecular Weight:
338.44
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.25
MDL number:
Product Name
Idebenone, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
methanol: 50 mg/mL, clear to slightly hazy
storage temp.
room temp
SMILES string
O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
InChI
1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
InChI key
JGPMMRGNQUBGND-UHFFFAOYSA-N
General description
Idebenone is a short-chain benzoquinone drug.
Application
Idebenone has been used:
- to treat mutant myocilin (mMYOC) cells for drug treatment assay
- to validate C2C12 secondary cell screening assay
- to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs
Biochem/physiol Actions
A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON). It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Idebenone maintains survival of mutant myocilin cells by inhibiting apoptosis
Guan Y, et al.
Chinese Medicine, 129(16), 2001-2001 (2016)
Mary Kearney et al.
The Cochrane database of systematic reviews, 4(4), CD007791-CD007791 (2012-04-20)
Friedreich ataxia is a rare inherited autosomal recessive neurological disorder, characterised initially by unsteadiness in standing and walking, slowly progressing to wheelchair dependency usually in the late teens or early twenties. It is associated with slurred speech, scoliosis and pes
Lucia Montenegro et al.
Molecular pharmaceutics, 9(9), 2534-2541 (2012-08-17)
The knowledge of the interactions between solid lipid nanoparticles (SLN) and cell membranes is important to develop effective carrier systems for drug delivery applications. Loading idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases, into SLN improves