M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Synonym(s):
MPO, Peroxidase, myelo
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About This Item
CAS Number:
NACRES:
NA.32
UNSPSC Code:
12352200
MDL number:
SMILES string
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
InChI key
JSPLKZUTYZBBKA-UHFFFAOYSA-N
biological source
human leucocytes
form
lyophilized powder
specific activity
≥50 units/mg protein
solubility
H2O: soluble, aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... MPO(4353)
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Analysis Note
Source material tested and found negative for antibody to HIV and for HBSAG.
Application
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Biochem/physiol Actions
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
General description
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Other Notes
Lysosomal heme-containing protein.
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Physical form
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Cytokine Kinetics and Other Host Factors in Response to Pneumococcal Pulmonary Infection in Mice
Bergeron Y, et al.
Clinical Microbiology Reviews, 66(3), 912-922 (1998)
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4.
Crooks SW
The European Respiratory Journal, 15(2), 274-280 (2000)
Michael S Runyon et al.
Thrombosis journal, 8, 3-3 (2010-02-26)
Experimental models of pulmonary embolism (PE) that produce pulmonary hypertension (PH) employ many different methods of inducing acute pulmonary occlusion. Many of these models induce PE with intravenous injection of exogenous impervious objects that may not completely reproduce the physiological
Avinash Khandagale et al.
Biology open, 7(7) (2018-06-28)
Patients with inflammatory bowel disease (IBD) are susceptible to thromboembolism. Interestingly, IBD occurs less frequently in patients with inherited bleeding disorders. Therefore, we analyzed whether F9-deficiency is protective against the onset of acute colitis in a genetic hemophilia B mouse
Myeloperoxidase and cardiovascular disease.
Nicholls SJ and Hazen SL
Arteriosclerosis, Thrombosis, and Vascular Biology, 25(6), 1102-1111 (2005)
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