SCP0152
Gastrin I (1-14)
≥92% (HPLC)
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C79H100N16O27
Molecular Weight:
1705.73
NACRES:
NA.32
UNSPSC Code:
51111800
assay
≥92% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
General description
Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.
Application
Gastrin I (1-14) has been used:
- as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture
- as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)
- in viable lymphocytes culture for re-stimulation assay
Biochem/physiol Actions
Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.
The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
C M Thorburn et al.
Gastroenterology, 115(2), 275-280 (1998-07-25)
Gastrin is a putative promoter of colorectal carcinomas. The aim of this study was to evaluate the temporal relationship between gastrinemia and development of colorectal malignancy. We conducted a nested case-control study among 128,992 subscribers to a health maintenance program
Zhi-Feng Miao et al.
Stem cells (Dayton, Ohio), 32(12), 3062-3074 (2014-08-22)
Peritoneal dissemination is the most common cause of death in gastric cancer patients. The hypoxic microenvironment plays a major role in controlling the tumor stem cell phenotype and is associated with patients' prognosis through hypoxia-inducible factor-1α (HIF-1α), a key transcriptional
Nicholas Osborne et al.
Cancer immunology, immunotherapy : CII, 68(10), 1635-1648 (2019-09-25)
Pancreatic cancer has been termed a 'recalcitrant cancer' due to its relative resistance to chemotherapy and immunotherapy. This resistance is thought to be due in part to the dense fibrotic tumor microenvironment and lack of tumor infiltrating CD8 + T cells. The