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SML1594

Cilengitide trifluoroacetic acid salt

≥95% (HPLC), vascular targeting agent, powder

Synonym(s):

2,2,2-trifluoroacetate, Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate, EMD 121974, NSC 707544, c(RGDF(NMe)V)

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About This Item

Empirical Formula (Hill Notation):
C27H40N8O7 · xC2HF3O2
CAS Number:
188968-51-6
Molecular Weight:
588.66 (free base basis)
UNSPSC Code:
12352106
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
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Product Name

Cilengitide trifluoroacetic acid salt, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

N1([C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C1=O)Cc2ccccc2)CC(=O)O)CCCN\C(=N\[H])\N)C(C)C)C

InChI

1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1

InChI key

AMLYAMJWYAIXIA-VWNVYAMZSA-N

Application

Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5.

Biochem/physiol Actions

Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist.
Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the αvβ3 and αvβ5 integrins.
It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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