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Merck

T7004

Thymidine 5′-monophosphate disodium salt hydrate

≥99%

Synonym(s):

5′-Thymidylic acid disodium salt, TMP, dTMP

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About This Item

Empirical Formula (Hill Notation):
C10H13N2Na2O8P · xH2O
CAS Number:
33430-62-5
Molecular Weight:
366.17 (anhydrous basis)
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
329826857
EC Number:
251-518-0
Beilstein/REAXYS Number:
4086927
MDL number:
MFCD09039259
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 100 mg/mL to clear, colorless
Storage temp.:
−20°C

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InChI key

KCOPAVKVHIWPKB-SPSULGLQSA-L

InChI

1S/C10H15N2O8P.2Na.H2O/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t6-,7+,8+;;;/m0.../s1

SMILES string

O.[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C(=O)NC1=O

biological source

synthetic (organic)

assay

≥99%

form

powder

solubility

H2O: 100 mg/mL to clear, colorless

storage temp.

−20°C

Quality Level

200

Related Categories

General description

Thymidine 5′-monophosphate de novo synthesis from deoxyuridine monophosphate (dUMP) is catalyzed by the enzyme thymidylate synthase.

Application

Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard for the quantification of metabolites from plasma and tumor interstitial fluid using liquid chromatography-mass spectrometry analysis (LC/MS). It has also been used as a single deoxy-mononucleotide to test its effect on the cell growth of human malignant intestinal CaCo-2 cells and normal rat intestinal cell line IEC-6 cells.
Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL8060
SLCK4009
SLCH7411
SLCG5545
SLCF7370

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