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Merck

157260

1-Hydroxybenzotriazole hydrate

98% dry basis wetted with not less than 14 wt. % water, for peptide synthesis

Sinónimos:

HOBt Hydrate

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Fórmula empírica (notación de Hill):
C6H5N3O · xH2O
Número CAS:
123333-53-9
Peso molecular:
135.12 (anhydrous basis)
MDL number:
MFCD00065690
UNSPSC Code:
12352000
PubChem Substance ID:
24849666
NACRES:
NA.22
EC Number:
219-989-7
Beilstein/REAXYS Number:
4515

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Nombre del producto

1-Hydroxybenzotriazole hydrate, wetted with not less than 14 wt. % water, 98% dry basis

SMILES string

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

InChI key

PJUPKRYGDFTMTM-UHFFFAOYSA-N

assay

98% dry basis

form

solid

quality

synthesis grade

reaction suitability

reaction type: Addition Reactions

mp

155-158 °C (lit.)

application(s)

peptide synthesis

Quality Level

200

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General description

1-Hydroxybenzotriazole hydrate is a derivative of benzotriazole primarily used as a coupling reagent in peptide synthesis.

Application

1-Hydroxybenzotriazole hydrate can be used as a reagent:
  • To synthesize β-peptides via microwave-assisted amino acid coupling.
  • In the spot synthesis of glycopeptides.
It can also be used as a deprotection agent for the removal of Fmoc (9-fluorenylmethoxycarbonyl) protecting group.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

supp_hazards

EUH044

Clase de almacenamiento

4.1A - Other explosive hazardous materials

wgk

WGK 1

flash_point_f

314.6 °F

flash_point_c

157 °C

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Certificados de análisis (COA)

Lot/Batch Number
WXBD6700V
WXBD3672V
WXBD0869V
WXBC8973V
WXBC6311V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Why is Product 157260, Hydroxybenzotriazole hydrate wet?

    Hydroxybenzotriazole hydrate is a solid that is explosive when dry. Our specification for this product is >14% water.

  6. Can Product 157260, Hydroxybenzotriazole hydrate, be dried?

    Drying hydroxybenzotriazole hydrate should not be attempted because of its explosive nature.

  7. How is Product 157260, Hydroxybenzotriazole hydrate, shipped?

    Hydroxybenzotriazole hydrate can not travel be sea or air. It is typically shipped by truck.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Tetrahedron Letters, 35, 3315-3315 (1994)
T Katoh et al.
International journal of peptide and protein research, 42(3), 264-269 (1993-09-01)
3-Dimethylphosphinothioyl-2(3H)-oxazolone (MPTO) was synthesized, and its ability to effect racemization-free couplings and cyclization of a peptide and its C-terminal epimer was examined. MPTO showed good reactivity in aprotic polar solvents such as N,N-dimethylformamide (DMF) and N-methylpyrrolidone. In reactivity MPTO resembles
Synlett, 733-733 (1993)
Tetrahedron Letters, 34, 6383-6383 (1993)
Injectable gel scaffold based on biopolymer microspheres via an enzymatic reaction.
Huaping Tan et al.
Advanced healthcare materials, 3(11), 1769-1775 (2014-05-17)
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