465119
Baicalein
98%
Sinónimos:
5,6,7-Trihydroxyflavone
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H10O5
Número CAS:
Peso molecular:
270.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
272683
Assay:
98%
Form:
solid
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Permítanos ayudarleNombre del producto
Baicalein, 98%
InChI
1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
SMILES string
Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI key
FXNFHKRTJBSTCS-UHFFFAOYSA-N
assay
98%
form
solid
mp
256-271 °C (lit.)
functional group
ketone
phenyl
Quality Level
Gene Information
mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)
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Categorías relacionadas
Application
Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.
Biochem/physiol Actions
The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.
General description
Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Nina M Høyland-Kroghsbo et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 131-135 (2016-11-17)
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Yefei Zhou et al.
Poultry science, 98(7), 2790-2799 (2019-02-20)
Baicalein, the main flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been demonstrated to exert multiple pharmacological effects, and thus could be utilized as a potential feed additive in broiler chickens. This study evaluated the effects of broiler
D E Shieh et al.
Anticancer research, 20(5A), 2861-2865 (2000-11-04)
Xanthine oxidase inhibitors are known to be therapeutically useful for the treatment of hepatitis and brain tumor. Baicalein, baicalin and wogonin, isolated from Scutellaria rivularis, have been reported to exhibit a strong activity on xanthine oxidase inhibition. In this study
Naheed Riaz et al.
Phytochemistry, 65(8), 1129-1135 (2004-04-28)
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.
Yuh-Chiang Shen et al.
European journal of pharmacology, 465(1-2), 171-181 (2003-03-26)
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied. Both baicalin and baicalein diminished fMLP- or PMA-induced reactive oxygen intermediates production in
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