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64046

2,3-Dimercapto-1-propanol

≥98% (iodometric)

Sinónimos:

BAL, British anti-Lewisite, DMP, Dimercaprol, Dithioglycerol

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Fórmula lineal:
HOCH2CH(SH)CH2SH
Número CAS:
59-52-9
Peso molecular:
124.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57651969
EC Number:
200-433-7
Beilstein/REAXYS Number:
1732058
MDL number:
MFCD00004864
Assay:
≥98% (iodometric)
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Quality Level

200

assay

≥98% (iodometric)

refractive index

n20/D 1.572-1.574, n20/D 1.573 (lit.)

bp

120 °C/15 mmHg (lit.)

density

1.239 g/mL at 25 °C (lit.)

functional group

hydroxyl, thiol

storage temp.

2-8°C

SMILES string

OCC(S)CS

InChI

1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

WQABCVAJNWAXTE-UHFFFAOYSA-N

General description

Dimercapto-1-propanol acts as a chelating agent and forms stable complexes with certain heavy metals, including arsenic, mercury, and lead.

Application

2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
82670
81500
62150
31050
80040

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S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
R Vos et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2736-2748 (2014-11-15)
Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
Megan O'Reilly et al.
American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 wk of gestation, the challenge of promoting lung growth
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