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Merck

T-074

3,3′,5-Triyodo-L-tironina

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

O-(4-Hidroxi-3-yodofenil)-3,5-diyodo-L-tirosina, Liotironina, T3

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Fórmula empírica (notación de Hill):
C15H12I3NO4
Número CAS:
6893-02-3
Peso molecular:
650.97
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329826618
MDL number:
MFCD00002593
Beilstein/REAXYS Number:
2710227

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InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

SMILES string

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

mp

234-238 °C (lit.)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... THRA(7067), THRB(7068)

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Application

The Certified Reference Material (CRM) in solution can also be used as follows:

  • Multi-residue determination of seven thyroid hormones in placenta samples by isotope dilution liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS)
  • Parts-per-trillion analysis of five thyroid hormones in zebrafish larvae by their solid phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray ionization- tandem mass spectrometric (UPLC-ESI/MS/MS) analysis
  • Simultaneous analysis of six free thyroid hormones in bovine serum samples by ultrafiltration and high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS)
  • Determination of six thyroid hormones in mouse tissue samples by isotope dilution nano-ultraperformance liquid chromatography–quadrupole time-of-flight mass spectrometry (Q-TOF-MS)
  • Identification and quantification of triiodothyronine and thyroxine in rat serum samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

General description

Certified Spiking Solutions® are suitable for use as a starting material in the preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.

3,3′,5-Triiodo-L-thyronine (T3) is a thyroid hormone and active form of L-thyroxine (T4), formed by deiodinase type I or II. It supports various physiological functions, such as oxygen consumption, carbohydrate metabolism, protein synthesis, and neural development. Free and total T3 serum levels are measured by LC-MS/MS for the determination of hyperthyroidism caused by excess T3.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Vasiliki Michopoulos et al.
Fertility and sterility, 99(7), 2084-2091 (2013-03-20)
To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
V N Buriak et al.
Likars'ka sprava, (5)(5), 58-63 (2013-03-29)
The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic
Min Kyong Moon et al.
European journal of endocrinology, 168(6), 805-810 (2013-03-21)
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. A total of 100 euthyroid men (free triiodothyronine
Min Wang et al.
Neuro endocrinology letters, 34(1), 62-70 (2013-03-26)
To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect. The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells
Susana B Bravo et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2431-2441 (2013-03-30)
Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available.
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