05-389
Anti-Rac1 Antibody, clone 23A8
clone 23A8, Upstate®, from mouse
Sinónimos:
Anti-Rac1
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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
23A8, monoclonal
Application:
IHC, IP, WB
Species reactivity:
rat, human, mouse
Citations:
360
Technique(s):
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
Uniprot accession no.:
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Permítanos ayudarlebiological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
23A8, monoclonal
species reactivity
rat, human, mouse
packaging
antibody small pack of 25 μg
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAC1(5879)
Categorías relacionadas
Application
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
G-proteins
Cytoskeletal Signaling
G-proteins
This Anti-Rac1 Antibody, clone 23A8 has been published in more than 40 citations and validated for use in Immunohistochemistry (IHC), Immunoprecipitation (IP) and Western Blotting (WB) for the detection of Rac1 protein.
Biochem/physiol Actions
Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.
Analysis Note
Control
Immunoblot/Immunoprecipitation: Rat brain microsomal protein preparation
Immunohistochemistry: Rat brain sections
Immunoblot/Immunoprecipitation: Rat brain microsomal protein preparation
Immunohistochemistry: Rat brain sections
routinely evaluated by immunoblot on rat brain microsomal protein preparation
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
21 kDa
Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.
Immunogen
Recombinant protein containing the full length human Rac
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Preparation Note
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells.
Villalba, M, et al.
The Journal of cell biology, 155, 331-338 (2001)
Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture.
O'Brien, WJ; Krema, C; Heimann, T; Zhao, H
Investigative Ophthalmology & Visual Science null
Evaluation of Rho family small G-protein activity induced by integrin ligation on human leukocytes.
Angela Gismondi, Fabrizio Mainiero, Angela Santoni
Methods in Molecular Biology null
H N Kovacic et al.
The Journal of biological chemistry, 276(49), 45856-45861 (2001-10-05)
Rac1 has been shown to activate a NADPH oxidase complex producing superoxide anions in a variety of mammalian cell types. We evaluated the impact of Rac1-induced reactive oxygen species production on the turnover of Rac1 itself in human aortic endothelial
Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action
Castoria, G., et al
The Journal of cell biology, 161, 547-556 (2003)
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 05-389 | 04053252729034 |
| 05-389-25UG | 04054839337789 |
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