Documentos clave

Ver Toda la documentación

475838

Mifepristone

Name: Mifepristone
Brand: MM

≥99% (titration), solid, progesterone and glucocorticoid receptor antagonist, Calbiochem^®

Sinónimos:

Mifepristone, (11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Cambiar Vistas

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₂₉H₃₅NO₂

Número CAS:

84371-65-3

Peso molecular:

429.59

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00867226

Assay:

≥99% (titration)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

Propiedades

Nombre del producto

Mifepristone, A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

Quality Level

100

description

Merck USA index - 14, 6186

assay

≥99% (titration)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

impurities

≤0.1% Steroid substances

color

yellow

solubility

ethanol: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(C)(C)c1ccc(cc1)[C@H]2C[C@]3([C@H]([C@@H]4CCC5=CC(=O)CCC5=C42)CC[C@@]3(O)C#CC)C

InChI

1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChI key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

Descripción

General description

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Progesterone and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

McCullers, D.L., et al. 2002. Neuroscience109, 219.
Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci.955, 159.
Gao, F., et al. 2001. Acta Pharmacol. Sin.22, 524.
Hyder, S.M., et al. 2001. Int. J. Cancer92, 469.
Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
Sridhar, S., et al. 2001. Cancer Res.61, 7179.
Behl, C., et al. 1997. Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997. Hum. Reprod.12, 1280.
Gruol, D.J., et al. 1994. Cancer Res.54, 3088.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Still not finding the right product?

Explore all of our products under

pictograms

GHS08

signalword

Danger

hcodes

H360

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c