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5.04914

CNQX

Name: CNQX
Brand: MM

Sinónimos:

CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline

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Fórmula empírica (notación de Hill):

C₉H₄N₄O₄

Número CAS:

115066-14-3

Peso molecular:

232.15

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00069232

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

Servicio técnico

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Propiedades

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white to yellow

solubility

DMSO: 25 mg/mL

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1C#N)=O)=O

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Descripción

General description

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Secondary Target
Kainate

Target K_i: 0.6 – 2.11 →M for GluA1 – 4 and Ki

Other Notes

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c