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Merck

MAB2605

Anti-ATG5 Antibody, clone 177.19

clone 177.19, from mouse

Sinónimos:

APG5 autophagy 5-like, APG5 autophagy 5-like (S. cerevisiae), APG5 (autophagy 5, S. cerevisiae)-like, ATG5 autophagy related 5 homolog (S. cerevisiae), ATG5 autophagy related 5-like, Apoptosis-specific protein

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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Nombre del producto

Anti-ATG5 Antibody, clone 177.19, clone 177.19, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

177.19, monoclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NM_004849.2

UniProt accession no.

Q9H1Y0

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ATG5(9474)

Analysis Note

Control
Western Blot and Immunoprecipitation: HeLa cell lysate.
Western Blot Analysis: 0.5 ug/mL of this antibody detected ATG5 on HeLa cell lysate.

Application

Immunoprecipitation: HeLa cell lysate
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-ATG5 Antibody, clone 177.19 is validated for use in WB, IP for the detection of ATG5.

Biochem/physiol Actions

Other species have not been tested.
The antibody reacts with the 50 kDa ATG5 protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

50 kDa
ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity

Immunogen

Linear Peptide, aa: 8-318

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: MABC137

Physical form

Format: Purified
Protein G Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Isabel Pombo Grégoire et al.
PLoS pathogens, 7(12), e1002422-e1002422 (2011-12-17)
Autophagy is a conserved degradative pathway used as a host defense mechanism against intracellular pathogens. However, several viruses can evade or subvert autophagy to insure their own replication. Nevertheless, the molecular details of viral interaction with autophagy remain largely unknown.

Contenido relacionado

Autophagy Research Focus

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"Recognizing both the tremendous opportunities and the challenges facing cancer research, we are dedicated to developing and refining tools and technologies for the study of cancer. With our comprehensive portfolio, including the Upstate®, Chemicon®, and Calbiochem® brands of reagents and antibodies, researchers can count on dependable, high quality solutions for analyzing all the hallmarks of cancer."

Número de artículo de comercio global

SKUGTIN
MAB260504053252398391

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