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Merck

MAB4601

Anti-Bax Antibody, NT, aa3-16 hBax protein, clone 2D2

clone 2D2, Chemicon®, from mouse

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2D2, monoclonal
Application:
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
human
Citations:
11
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Uniprot accession no.:
Q07812

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Nombre del producto

Anti-Bax Antibody, NT, aa3-16 hBax protein, clone 2D2, clone 2D2, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2D2, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_004324.3
NM_138761.2
NM_138763.2
NM_138764.2
NM_138765.2

UniProt accession no.

Q07812

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BAX(581)

Application

Anti-Bax Antibody, N-terminus, aa3-16 hBax protein, clone 2D2 is an antibody against Bax for use in IF, WB, IH(P).
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
Western blot: 1 μg/ml for 2 hours at RT (1:200 dilution)

Immunofluorescence

Immunohistochemistry (frozen and paraffin): 2-4 μg/ml for 30 minutes at RT

(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min. followed by cooling for 20 min. at RT)

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Recognizes a 21 kD protein. Does not cross-react with Bcl-2a or Bcl-X. In contrast to Bcl-2a and Bcl-X, overexpression of Bax protein accelerates apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The previously assigned protein identifier Q07814 has been merged into Q07812. Full details can be found on the UniProt database.

Immunogen

Epitope: N-terminus, aa3-16 hBax protein
Synthetic peptide corresponding to aa 3-16 (GSGEQPRGGGPTSS) of human bax. This amino acid sequence is not shared by mouse or rat Bax.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-434

Physical form

Format: Purified
Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 15 mM sodium azide.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.
Yamaguchi, R; Lartigue, L; Perkins, G; Scott, RT; Dixit, A; Kushnareva, Y; Kuwana et al.
Molecular Cell null
Sabrina L Spencer et al.
Nature, 459(7245), 428-432 (2009-04-14)
In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein concentrations. In mammalian cells, protein levels also vary and individual cells differ widely in their responsiveness to uniform physiological stimuli. In the case of apoptosis mediated by
Maotao Du et al.
Annals of translational medicine, 9(23), 1722-1722 (2022-01-25)
Aloe-emodin is reported as a potential cancer therapeutic agent due to its inhibition of the proliferation, migration, and invasion of cancer cells. This study aimed to confirm the effects of aloe-emodin on the progression of melanoma and identify the underlying
Suzanne Gaudet et al.
PLoS computational biology, 8(4), e1002482-e1002482 (2012-05-10)
Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability manifests itself as dramatic differences in the time between ligand exposure and the
Marc Payton et al.
Molecular cancer therapeutics, 17(12), 2575-2585 (2018-09-30)
Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers, including acute myeloid leukemia (AML). In this study, pan-aurora kinase inhibitor (AKI) AMG 900 distinguishes itself as an anti-leukemic
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SKUGTIN
MAB460104053252359361

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