08984
Butyryl-L-carnitine
analytical standard
Sinónimos:
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxobutoxy)-1-propanaminium inner salt, Butanoyl-L-carnitine, C4-Carnitine
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Fórmula empírica (notación de Hill):
C11H21NO4
Número CAS:
Peso molecular:
231.29
UNSPSC Code:
41116107
NACRES:
NB.21
MDL number:
Servicio técnico
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analytical standard
Quality Level
assay
≥97.0% (HPLC)
optical activity
[α]/D -23.0±2.0°, c = 0.1 in H2O
shelf life
limited shelf life, expiry date on the label
impurities
≤10.0% water
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
C[N+](C)(C)C[C@H](OC(CCC)=O)CC([O-])=O
InChI
1S/C11H21NO4/c1-5-6-11(15)16-9(7-10(13)14)8-12(2,3)4/h9H,5-8H2,1-4H3/t9-/m1/s1
InChI key
QWYFHHGCZUCMBN-SECBINFHSA-N
General description
Butyryl-L-carnitine is a naturally occurring compound belonging to the acylcarnitine class of compounds as listed in the human metabolome database (HMBD). These compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency. It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
Application
Butyryl-L-carnitine may be used as an analytical reference standard for the separation and identification of underivatized butyryl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). It may also be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Metabolomic analyses reveal extensive progenitor cell deficiencies in a mouse model of duchenne muscular dystrophy
Joseph J, et al.
Metabolites, 8(4), 61-61 (2018)
Exogenous carnitine application augments transport of fatty acids into mitochondria and stimulates mitochondrial respiration in maize seedlings grown under normal and cold conditions
Turk H, et al.
Cryobiology, 9, 97-103 (2019)
Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable