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Merck

33429

Doxiciclina hyclate

VETRANAL®, analytical standard

Sinónimos:

Clorhidrato de doxiciclina hemietalonato hemihidratado

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Fórmula empírica (notación de Hill):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
Número CAS:
24390-14-5
Peso molecular:
512.94
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754541
MDL number:
MFCD07357237
Beilstein/REAXYS Number:
5702728

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InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

SMILES string

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI key

HALQELOKLVRWRI-ZVACAFRPSA-N

grade

analytical standard

agency

EPA 1694

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

solubility

DMSO: soluble 100 mM

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

application(s)

clinical testing

format

neat

mode of action

protein synthesis | interferes

Quality Level

100

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Categorías relacionadas

Biochem/physiol Actions

Modo de acción: El hiclato de doxicilina inhibe la respuesta inflamatoria a la enfermedad de Lyme, causada por la espiroqueta Borrelia burgdorferi

. Espectro de actividad: Eficaz contra un inhibidor de amplio espectro de las metaloproteinasas de la matriz in vivo.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Chemical structure: tetracycline

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCF3190
BCBW2091
BCBS7684V
BCBS3626V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is doxycycline hyclate soluble in DMSO?

    According to literature sources, doxycycline hyclate is soluble in DMSO at a concentration of 100 mM.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Erdinc Turk et al.
Animals : an open access journal from MDPI, 10(6) (2020-07-01)
The aims of this study in goats were to determine the pharmacokinetics of doxycycline hyclate following single intravenous (IV), intramuscular (IM) and oral administrations of 20 mg/kg and to evaluate the pharmacokinetics and accumulation of doxycycline hyclate after repeated oral
Hanumara Ram Chowdri et al.
Annals of internal medicine, 159(1), 21-27 (2013-07-03)
The diverse tickborne infections of the northeastern United States can present as undifferentiated flu-like illnesses. In areas endemic for Lyme and other tickborne diseases, patients presenting with acute febrile illness with myalgia, headache, neutropenia, thrombocytopenia, and elevated hepatic aminotransferase levels
Alicia Anderson et al.
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 62(RR-03), 1-30 (2013-03-29)
Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in the United
C Arnoud Meijer et al.
Annals of internal medicine, 159(12), 815-823 (2014-02-04)
Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. To test whether doxycycline inhibits AAA progression in humans. Randomized, placebo-controlled, double-blind
Xuefeng Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13870-13875 (2014-09-06)
Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for
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