33586
Flunixin
VETRANAL®, analytical standard
Sinónimos:
2-[2-Methyl-3-(trifluoromethyl)phenylamino]nicotinic acid
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C14H11F3N2O2
Número CAS:
Peso molecular:
296.24
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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Permítanos ayudarleInChI
1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
SMILES string
Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
InChI key
NOOCSNJCXJYGPE-UHFFFAOYSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
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Application
Flunixin may be used as a reference standard for the determination of NSAID drug, flunixin in biological samples using high-performance liquid chromatography with diode array detection (HPLC-DAD)/particle beam mass spectrometry (PB-MS)/atmospheric pressure ionization mass spectrometry (API-MS) and gas chromatography coupled to mass spectrometry (GC-MS).
Flunixin may be used as an analytical reference standard for the determination of flunixin in:
- Bovine muscle samples by hydrophilic interaction liquid chromatography-electrospray-tandem mass spectrometry (HILIC-ESI-MS/MS) equipped with selected reaction monitoring (SRM) detection.
- Animal tissues by dispersive-solid phase extraction (d-SPE) and enhanced matrix removal for lipids (EMR-L), followed by analysis using ultra-high performance liquid chromatography-triple quadrupole or quadrupole-time-of-flight (UHPLC-QqQ or UHPLC-Q/TOF) methods in conjunction with ESI-MS/MS operating on multiple reaction monitoring (MRM) mode of detection as well as ESI-LC-MS/MS with SRM detection mode.
- Porcine muscle samples by ESI-LC-MS/MS with MRM detection mode.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Flunixin is a potent nonsteroidal anti-inflammatory drug, primarily used as an anti-inflammatory agent and analgesic for the short-term treatment of moderate pain and inflammation in farm animals. It is also effective in inhibiting the synthesis of prostaglandins.
Flunixin is classified under the group of non-steroidal anti-inflammatory drugs (NSAIDs).
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Online eluent-switching technique coupled anion-exchange liquid chromatography-ion trap tandem mass spectrometry for analysis of non-steroidal anti-inflammatory drugs in pig serum.
Chang KC, et al.
Journal of Chromatography A, 1422, 222-229 (2015)
C Beretta et al.
Pharmacological research, 52(4), 302-306 (2005-06-09)
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of
Eva Weiss et al.
Journal of the science of food and agriculture, 96(6), 2230-2239 (2015-07-16)
Diet influences the porcine intestinal microbial ecosystem. Barrows were fitted with ileal T-cannulas to compare short-term effects of eight different wheat or barley genotypes and period-to-period effects on seven bacterial groups in ileal digesta and faeces by qPCR. Within genotypes
Simultaneous analysis of flunixin, naproxen, ethacrynic acid, indomethacin, phenylbutazone, mefenamic acid and thiosalicycic acid in plasma and urine by high-performance liquid chromatography and gas chromatography?mass spectrometry.
Singh KA, et al.
Analyst, 568(2), 351-361 (1991)
Nicholas W Gilpin et al.
Addiction biology, 19(4), 587-592 (2012-12-18)
Humans escalate their cigarette smoking over time, and a major obstacle in the field of pre-clinical nicotine addiction research has been the inability to produce escalated nicotine self-administration in rats. In experiment 1, male Wistar rats were trained to respond
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