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Merck

49761

Spermidine

analytical standard

Sinónimos:

1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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Fórmula lineal:
NH2(CH2)3NH(CH2)4NH2
Número CAS:
124-20-9
Peso molecular:
145.25
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329757521
EC Number:
204-689-0
Beilstein/REAXYS Number:
1698591
MDL number:
MFCD00008229

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InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

SMILES string

NCCCCNCCCN

grade

analytical standard

assay

≥97.5% (NT), ≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.479 (lit.)

density

0.925 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Spermidine may be used as one of the reference standard for the determination of spermidine in biological samples by high performance liquid chromatography-electrospray ionization–ion trap tandem mass spectrometry (HPLC–ESI–ITMS/MS).

Disclaimer

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

General description

Spermidine is a naturally occurring polyamine compound commonly found in food. It is essential for cell growth and survival.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Clase de almacenamiento

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number
BCCG3819
BCCF5855
BCCD8632
BCCD2772
BCCB7355

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Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography?electrospray ionization?ion trap tandem mass spectrometry (HPLC?ESI?ITMS/MS).
Ibarra A A G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1002, 176-184 (2015)
Micro-scale strategy to detect spermine and spermidine by MALDI?TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC?MS/MS after treatment with spermine and spermidine
Su H H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 978, 131-137 (2015)
Varun K Gupta et al.
Nature neuroscience, 16(10), 1453-1460 (2013-09-03)
Age-dependent memory impairment is known to occur in several organisms, including Drosophila, mouse and human. However, the fundamental cellular mechanisms that underlie these impairments are still poorly understood, effectively hampering the development of pharmacological strategies to treat the condition. Polyamines
Eugenia Morselli et al.
Aging, 1(12), 961-970 (2010-02-17)
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that
Andrew Breakspear et al.
The Plant cell, 26(12), 4680-4701 (2014-12-21)
Nitrogen-fixing rhizobia colonize legume roots via plant-made intracellular infection threads. Genetics has identified some genes involved but has not provided sufficient detail to understand requirements for infection thread development. Therefore, we transcriptionally profiled Medicago truncatula root hairs prior to and
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