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Merck

BP466

Vitamina B12

British Pharmacopoeia (BP) Assay Standard

Sinónimos:

α-(5,6-Dimetilbencimidazolil)cianocobamida, CN-Cbl, Cianocob(III)alamina, Cianocobalamina

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C63H88CoN14O14P
Número CAS:
Peso molecular:
1355.37
NACRES:
NA.24
UNSPSC Code:
41116107
MDL number:
EC Number:
200-680-0
Beilstein/REAXYS Number:
4122889
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InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

grade

pharmaceutical primary standard

API family

cyanocobalamin

form

solid

manufacturer/tradename

BP

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

color

light red

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Cyanocobalamin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Cyanocobalamin Tablets
  • Cyanocobalamin Oral Solution
  • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Cyanocobalamin is a water soluble vitamin, which plays an important role in animal and plant metabolism.

    Other Notes

    Sales restrictions may apply.

    Packaging

    Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Clase de almacenamiento

    11 - Combustible Solids

    wgk

    WGK 1


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    Ultramicrodetermination of cyanocobalamin in elemental diet by solid-phase extraction and high-performance liquid chromatography with visible detection
    Iwase H
    Journal of Chromatography A, 590(2), 359-363 (1992)
    Quantitative simultaneous estimation of water-soluble vitamins, Riboflavin, Pyridoxine, Cyanocobalamin and Folic Acid in neutraceutical products by HPLC
    Perveen S, et al.
    The Open Analytical Chemistry Journal, 3, 1-5 (2009)
    Maxim A Shevtsov et al.
    Journal of biomedical materials research. Part A, 102(9), 3033-3048 (2013-10-12)
    Angio- and osteogenesis following the two-stage (TS) implantation of the skin- and bone-integrated pylon seeded with autologous fibroblasts was evaluated. Two consecutive animal substudies were undertaken: intramedullary subcutaneous implantation (15 rabbits) and a TS transcutaneous implantation (12 rabbits). We observed
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    PloS one, 9(5), e97571-e97571 (2014-05-17)
    Regular intravenous immunoglobulin treatment is used to replace antibody deficiency in primary immunodeficiency diseases; however the therapeutic effect seems to be related not only to antibody replacement but also to an active role in the modulation of the immune response.

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