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Merck

PHR1054

(−)-Riboflavina

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Lactoflavina, Vitamina B2, Vitamina G

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Fórmula empírica (notación de Hill):
C17H20N4O6
Número CAS:
83-88-5
Peso molecular:
376.36
NACRES:
NA.24
PubChem Substance ID:
329823084
eCl@ss:
34058005
UNSPSC Code:
41116107
EC Number:
201-507-1
MDL number:
MFCD00005022
Beilstein/REAXYS Number:
97825

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InChI key

AUNGANRZJHBGPY-SCRDCRAPSA-N

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

SMILES string

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. R060000, traceable to USP 1603006

API family

riboflavin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

290 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Riboflavin may also be used as a reference standard for the determination of the analyte in cooked sausages and energy drinks by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0268 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Determination of total riboflavin in cooked sausages
Valls F, et al.
Journal of Agricultural and Food Chemistry, 47(3), 1067-1070 (1999)
Rapid method for determination of riboflavin in urine by high-performance liquid chromatography
Smith DM, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 182(3), 285-291 (1980)
Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry
Aranda M and Morlock G
Journal of Chromatography A, 1131(1-2), 253-260 (2006)
Zisis Gatzioufas et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 846-848 (2013-10-31)
To investigate the effect of high-fluence corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A in the management of progressive keratoconus. Preliminary results from a prospective cohort study. Seven eyes from 7 patients with progressive keratoconus subjected to CXL were included.
Carol P Wilson et al.
Hypertension (Dallas, Tex. : 1979), 61(6), 1302-1308 (2013-04-24)
Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Whether this effect is
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