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Merck

PHR1253

Acarbose

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Acarbose, 4",6"-Dideoxy-4"-([1S]-[1,4,6/5]-4,5,6-trihydroxy-3-hydroxymethyl-2-yclohexenylamino)-maltotriose

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Fórmula empírica (notación de Hill):
C25H43NO18
Número CAS:
56180-94-0
Peso molecular:
645.60
NACRES:
NA.24
PubChem Substance ID:
329823256
UNSPSC Code:
41116107
EC Number:
260-030-7
MDL number:
MFCD00869592

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InChI key

XUFXOAAUWZOOIT-SXARVLRPSA-N

InChI

1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]4C=C(CO)[C@@H](O)[C@H](O)[C@H]4O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000500, traceable to USP 1000521

API family

acarbose

CofA

current certificate can be downloaded

analyte chemical class(es)

oligosaccharides

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... AMY2A(279), MGAM(8972)

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Acarbose may be used as a pharmaceutical reference standard in determining the concentration of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Modified tetrasaccharide that acts as a reversible α -glucosidase inhibitor.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acarbose is an oral antidiabetic drug, a glucosidase inhibitor used in the management of non-insulin-dependent diabetes mellitus (NIDDM).

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9057 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets.
Cherkaoui S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 18(4-5), 729-735 (1998)
Analysis of the antidiabetic drug acarbose by capillary electrophoresis.
Rethfeld I and Blaschke G
Journal of Chromatography. B, Biomedical Sciences and Applications, 700(1-2), 249-253 (1997)
High performance liquid chromatography of acarbose and its metabolite on porous graphitic carbon column.
Daali Y, et al.
Journal of Separation Science, 25(5-6), 280-284 (2002)
Ashley S Boath et al.
Food chemistry, 135(3), 929-936 (2012-09-08)
Polyphenol-rich extracts from certain berries inhibited α-glucosidase activity in vitro. The two most effective berry extracts, from black currant and rowanberry, inhibited α-glucosidase with IC(50) values respectively of 20 and 30μg GAE/ml and were as effective as the pharmaceutical inhibitor
Henriëtte J Rozeboom et al.
The Journal of biological chemistry, 288(37), 26764-26774 (2013-08-02)
α-1,4-Glucan lyase (EC 4.2.2.13) from the red seaweed Gracilariopsis lemaneiformis cleaves α-1,4-glucosidic linkages in glycogen, starch, and malto-oligosaccharides, yielding the keto-monosaccharide 1,5-anhydro-D-fructose. The enzyme belongs to glycoside hydrolase family 31 (GH31) but degrades starch via an elimination reaction instead of
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