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Merck

PHR1273

Malic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

DL-Malic acid, (±)-2-Hydroxysuccinic acid, DL-Hydroxybutanedioic acid

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Fórmula lineal:
HO2CCH2CH(OH)CO2H
Número CAS:
6915-15-7
Peso molecular:
134.09
NACRES:
NA.24
E Number:
E296
PubChem Substance ID:
329823269
UNSPSC Code:
41116107
EC Number:
230-022-8
MDL number:
MFCD00064212
Beilstein/REAXYS Number:
1723539

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InChI key

BJEPYKJPYRNKOW-UHFFFAOYSA-N

InChI

1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)

SMILES string

OC(CC(O)=O)C(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000143, traceable to USP 1374601

vapor density

4.6 (vs air)

vapor pressure

<0.1 mmHg ( 20 °C)

API family

malic acid

CofA

current certificate can be downloaded

autoignition temp.

644 °F

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

131-133 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Malic acid is a naturally occurring acidulant and low acid food additive, present in most fruits and vegetables. It is widely used to enhance the flavor, adjust the pH value of alkaline products and to control the growth of bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0009 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

397.4 °F

flash_point_c

203 °C

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Bina Lee et al.
Immunopharmacology and immunotoxicology, 41(6), 614-621 (2019-10-28)
Background: dl-Malic acid (dl-M) is used widely in cosmetic formulations as a pH-adjuster or as a preservative. dl-M is used as an exfoliator in the form of α-hydroxy acids. However, the role of dl-M in skin diseases (including atopic dermatitis
Fundamentals of Food Biotechnology (2014)
Prasanta Dey et al.
Biomolecules, 10(9) (2020-09-04)
Renal cell carcinoma has emerged as one of the leading causes of cancer-related deaths in the USA. Here, we examined the anticancer profile of oxindole derivatives (SH-859) in human renal cancer cells. Targeting 786-O cells by SH-859 inhibited cell growth
Hugo Oliveira et al.
PloS one, 9(10), e108376-e108376 (2014-10-08)
Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes a Salmonella phage endolysin (Lys68) and demonstrates its potential antimicrobial effectiveness when combined with organic acids towards
M Taillefer et al.
Applied and environmental microbiology, 81(7), 2423-2432 (2015-01-27)
Clostridium thermocellum produces ethanol as one of its major end products from direct fermentation of cellulosic biomass. Therefore, it is viewed as an attractive model for the production of biofuels via consolidated bioprocessing. However, a better understanding of the metabolic
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