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Merck

PHR1281

Albendazole

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Methyl 5-(propylthio)-2-benzimidazolecarbamate

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Fórmula empírica (notación de Hill):
C12H15N3O2S
Número CAS:
54965-21-8
Peso molecular:
265.33
NACRES:
NA.24
PubChem Substance ID:
329823277
UNSPSC Code:
41116107
EC Number:
259-414-7
MDL number:
MFCD00083232

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InChI key

HXHWSAZORRCQMX-UHFFFAOYSA-N

InChI

1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

SMILES string

CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0325100, traceable to USP 1012553

API family

albendazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Albendazole (ABZ) is an anthelminthic drug, used in both human and veterinary medication. it is widely used to eliminated the effects of lymphatic filariasis.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0016 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Oral

target_organs

Adrenal gland,Blood,male reproductive organs,spleen

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ahmed M Abdel-tawab et al.
British journal of clinical pharmacology, 68(5), 737-742 (2009-11-18)
Albendazole (ABZ) is used in several anthelminthic drug programs. ABZ side-effects are generally mild, but ABZ-induced pancytopenia may be serious. In filariasis programmes, it may be necessary to administer ABZ to breastfeeding women. Few data are available on safety of
Franziska A Bieri et al.
The New England journal of medicine, 368(17), 1603-1612 (2013-04-26)
Soil-transmitted helminths are among the most prevalent sources of human infections globally. We determined the effect of an educational package at rural schools in Linxiang City District, Hunan province, China, where these worms are prevalent. The intervention aimed to increase
Aprilianto E Wiria et al.
PloS one, 8(3), e57899-e57899 (2013-03-26)
Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy. A household-based cluster-randomized, double-blind, placebo-controlled trial
Ruth Ann Baird et al.
Neurology, 80(15), 1424-1429 (2013-04-10)
To review the evidence base for different treatment strategies in intraparenchymal neurocysticercosis in adults and children. A literature search of Medline, EMBASE, LILACS, and the Cochrane Database from 1980 to 2008, updated in 2012, resulted in the identification of 10
Marlieke E A de Kraker et al.
Tropical medicine & international health : TM & IH, 11(5), 718-728 (2006-04-28)
To determine the efficacies of combinations of ivermectin or diethylcarbamazine and albendazole, which are recommended for use in mass treatment programmes against lymphatic filariasis. Review of published trends in microfilarial (mf) intensities after treatment with these combination therapies. By fitting
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