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Merck

PHR1418

Ácido succínico

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Ácido butanodióico

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Fórmula lineal:
HOOCCH2CH2COOH
Número CAS:
Peso molecular:
118.09
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-740-4
Beilstein/REAXYS Number:
1754069
MDL number:
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InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

SMILES string

OC(=O)CCC(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1623411

API family

succinic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

235 °C (lit.)

Quality Level

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Succinic acid is a dicarboxylic acid, which is used primarily as an acidity regulator in the food and beverage industry. Pharmaceutically, it is usually used as a conjugate feeder acid to form succinate salt and as an excipient.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Succinic acid may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2952 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Optimization and validation of an HPLC-photodiode array detector method for determination of organic acids in vinegar
Zong Y, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 98(2), 422-430 (2015)
Determination of lactic, acetic, succinic, and citric acids in table olives by HPLC/UV
Cunha SC, et al.
Journal of Liquid Chromatography and Related Technologies, 24(7), 1029-1038 (2001)
Food additives data book
Food additives data book, 56, 66-69 (2003)
Simultaneous Determination of Succinic Acid and Water-Soluble Vitamins by Ion-Pair High-Performance Liquid Chromatography
Leonov KA
Journal of Analytical Chemistry, 73(4), 358-363 (2018)
Simultaneous HPLC determination of organic acids, sugars and alcohols
Doyon G
Can. Inst. Food Sci Technol. J., 24(1-2), 87-94 (1991)

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