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Histamine dihydrochloride

Name: Histamine dihydrochloride
Brand: SIGMA

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

Sinónimos:

2-(4-Imidazolyl)ethylamine dihydrochloride

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Fórmula empírica (notación de Hill):

C₅H₉N₃ · 2HCl

Número CAS:

56-92-8

Peso molecular:

184.07

NACRES:

NA.77

PubChem Substance ID:

329757931

eCl@ss:

32160406

UNSPSC Code:

12352116

EC Number:

200-298-4

MDL number:

MFCD00012703

Beilstein/REAXYS Number:

3624116

Assay:

≥99.0% (AT)

Form:

powder or crystals

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Propiedades

Nombre del producto

Histamine dihydrochloride, ≥99.0% (AT)

assay

≥99.0% (AT)

form

powder or crystals

ign. residue

≤0.2%

loss

≤0.2% loss on drying, 20 °C (HV)

mp

244-247 °C, 249-252 °C (lit.)

solubility

H₂O: 0.1 g/mL, clear, colorless

anion traces

sulfate (SO₄^2-): ≤200 ppm

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Descripción

General description

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

Biochem/physiol Actions

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

Other Notes

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H317,H319,H334,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c